Fresh analysis suggests that individuals who stop using new slimming jabs like semaglutide or tirzepatide can put back on lost weight at a significantly accelerated pace than those who end conventional diet and exercise plans.
Findings released in a prominent health publication points out that while obese individuals often shed substantial amounts of their total mass while on the medication, the mass is regained at an average rate of nearly a kilo each month after stopping.
"People purchasing these medications must be cognizant of the risk of fast rebound weight gain when the therapy is stopped," warns lead investigator Dr. Susan Jebb.
Such speed of regain implies a reversion to starting weight in about 18 months.
Analyzing Approaches
The analysis, which looked at dozens of studies involving thousands of participants, compared the results of these new drugs with conventional dieting.
Researchers note that individuals who shed pounds through lifestyle changes alone usually have a slower weight regain—perhaps 0.1 kg a month—post-intervention.
Understanding the Quick Rebound
Experts propose the mechanism of the jabs accounts for the heightened regain.
The injections mimic a natural hormone called GLP-1, which moderates feelings of fullness.
"Sustained high doses of the hormone concentrations several times higher than the body's typical production may cause the body to generate a reduced amount of its endogenous GLP-1, and could lessen sensitivity to its actions," noted Dr. Adam Collins, a nutrition expert.
"Stopping of this hormone supplement results in appetite is no longer kept in check, making binge eating far more likely."
A Lifelong Condition?
The NHS recommend the jabs for individuals with obesity-related medical conditions, accompanied by recommended diet and exercise modifications.
A number of clinicians contend that, due to the high risk of weight regain, the therapy should be considered life-long.
This view is supported by drug manufacturers, who state that the results "underscore the persistent character of obesity," comparing it to managing diseases like high blood pressure.
Patient Testimonies
Individuals who have discontinued the medication report a powerful resurgence of hunger.
"I experienced a switch that goes on and I was suddenly starving," said an individual.
This challenge is compounded if patients have not established sustainable lifestyle or habit changes during treatment.
Growing Interest
Figures suggest that a significant number of adults in the UK have tried these injections in the last 12 months, with demand remaining high.
- Use is higher among females than males.
- The middle-aged demographic shows the highest usage rates.
- Many obtain the drugs through private prescriptions rather than public health services.
Ultimately, experts caution that while the jabs are effective agents for shedding pounds, they are not a magic fix and maintained weight loss hinges on integrated behavioural changes.
